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Indonesian Journal of Critical and Emergency Medicine Vol 1 No.2 June-August 2014 / ISSN : 2355-4584

Perbedaan Fungsi Paru pada Penderita Sindroma Metabolik dan Tanpa Sindroma Metabolik


Tri Setiana
Luthfan Budi Purnomo, Eko Budiono

ABSTRACT
Background:
Metabolic syndrome is a combination of central obesity, elevated blood pressure, impaired glucose metabolism, and dyslipidemia. Its prevalence is increasing worldwide. Several previous studies showed various differences of lung functions in patients with and without metabolic syndrome .
Objective: To determine whether patients with metabolic syndrome had lower FEV1 percent predicted and FVC percent predicted than normal population.
Methods: The study design was cross-sectional study. Patients were grouped into subjects with and without metabolic syndrome who met the inclusion and exclusion criteria.
Results: There were 96 subjects of the study with a mean age of 42.74 ± 9.14. Metabolic syndrome group consisted of 48 subjects and there were 48 healthy subjects in control group. FVC percent predicted values in subjects with and without metabolic syndrome were 99.27 ± 20.35 vs. 116.22 ± 20.67 (p < 0.001), and FEV1 values were 116.05
± 23.77 vs 130.06 ± 20.78 (p = 0.03). In patients with metabolic syndrome, 16.7% had FEV1 < 80% predicted that indicated decline in lung function (obstruction type), and 22.67% had FVC < 80 % predicted indicating a decline in lung function (restriction type).
Conclusion: Patient with metabolic syndrome had lower FEV1 and FVC values than normal population.
Keywords: Metabolic syndrome, pulmonary functions
 

ABSTRAK
Latar Belakang:
Sindroma metabolik merupakan kombinasi obesitas sentral, peningkatan tekanan darah, gangguan metabolisme glukosa, dan dislipidemia. Prevalensi sindroma metabolik semakin meningkat di seluruh dunia. Beberapa penelitian sebelumnya menunjukkan adanya kontroversi mengenai perbedaan fungsi paru pada pasien dengan sindroma metabolik dan tanpa sindroma metabolik.
Tujuan: mengetahui apakah pasien sindroma metabolik memiliki FEV1 persen prediksi dan FVC persen prediksi lebih rendah dibanding populasi normal.
Metode: Penelitian ini merupakan penelitian potong lintang dengan subjek penelitian penderita sindroma metabolik dan tanpa sindroma metabolik yang memenuhi kriteria inklusi dan eksklusi.
Hasil: Didapatkan total 96 subjek penelitian dengan rerata usia 42,7 ± 9,1 tahun. Subjek dikelompokkan menjadi kelompok sindroma metabolik sebanyak 48 subjek dan 48 lainnya sebagai kontrol sehat. FVC persen prediksi pada sindroma metabolik dan tanpa sindroma metabolik sebesar 99,27±20,35 vs. 116,22±20,67 (p<0,001), dan FEV1 sebesar 116,05±23,77 vs 130,06±20,78 (p=0,03). Sebanyak 16,7% subjek dengan sindroma metabolik memiliki FEV1 <80% prediksi yang menunjukkan adanya penurunan fungsi paru tipe obstruksi, dan 22,67% subjek memiliki FVC<80% prediksi, yang menunjukkan adanya penurunan fungsi paru tipe restriksi.
Kesimpulan: Pasien dengan sindroma metabolik mempunyai FEV1 dan FVC lebih rendah dibanding populasi normal.
Kata kunci: sindroma metabolik, fungsi paru


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